Essential component of intercellular cement that helps hoof integrity?

• A. Zinc, copper
• B. Intercellular cement
• C. Biotin
• D. Laminitis

Answer: (C)

Biotin supports the health of hoof horn by promoting keratin production and, crucially, the lipid components that form the intercellular cement between horn cells. The intercellular cement is largely lipid-rich (including ceramides and fatty acids) and acts as the glue that binds keratinocytes together, giving the hoof wall its toughness and resilience. Biotin functions as a cofactor in carboxylase enzymes that drive fatty acid synthesis and lipid metabolism in keratinocytes, helping to build and maintain that lipid matrix. When biotin is adequate, the intercellular cement strengthens, improving hoof integrity and reducing brittleness and cracks. Deficiencies lead to poor horn quality, so supplementation can specifically reinforce the cement between horn cells, making it the best choice.